GeneCards is a searchable, integrated database of human genes that provides concise genomic related information, on all known and predicted human genes.

The GeneCards human gene database extracts and integrates a carefully selected subset of gene related transcriptomic, genetic, proteomic, functional and disease information, from dozens of relevant sources. It provides robust user-friendly access to up-to-date knowledge. GeneCards overcomes barriers of data format heterogeneity, and uses standard nomenclature and approved gene symbols. GeneCards presents a complete summary for each gene, and provides the means to obtain a deep understanding of biology and medicine. Information is featured in 20 GeneCards sections.

GeneCards Suite

GeneNote, GeneAnnot, GeneLoc and GeneTide, GeneALaCart and GeneDecks are a suite of specialized databases and applications that are integrated with GeneCards®. These databases concentrate on gene expression in normal human tissues, gene microarray annotation, gene location and organization and analysis of Expressed Sequence Tags.

• GeneDecks: Explore sets of GeneCards genes
• GeneALaCart: Generates a file of GeneCards annotations for your list of genes
• GeneLoc: Presents an integrated map for each human chromosome, based on data integrated by the GeneLoc algorithm
• GeneNote: A database of human genes and their expression profiles in healthy tissues
• GeneAnnot: Provides a revised and improved annotaion of Affymetrix probe-sets from HG-U95,HG-U133 Plus 2.0
• GeneTide: An automated system for human transcripts (mRNA & ESTs) annotation and elucidation of de-novo genes

Pandatox

The PanDaTox database aims at identifying genes and intergenic regions that are unclonable in E. coli, to aid in the discovery of new antibiotics and biotechnologically beneficial functional genes.

PanDaTox is a database of genes that are potentially toxic to bacteria. The construction of this database is based on computational methods that scan a microbial genome and detect specific genes that kill E. coli if cloned into it. These methods identify genes and intergenic regions that fail to propagate in E. coli in the process of whole genome shotgun sequencing, thus creating sequencing gaps. It has been shown that these sequencing gaps are frequently caused by toxic genes, which may have antimicrobial properties.

PanDaTox holds and presents a set of >40,000 genes that may be toxic to bacteria. These genes are the result of a computational analysis performed on ~400 microbial genomes. Users can search for toxic genes in their genome of interest; check who are the homologs of these toxic genes and whether these homologs are toxic as well; query the database using a keyword-based search for genes answering to specific user-supplied criteria; and perform a sequence-based search (blast) for genes in the database that are similar to a query gene of their choice. The toxicity information for each gene is presented in both numerical and graphical manners, and details on each gene, including its DNA sequence, protein sequence, and various links to external web sources are presented.